Document Detail

Moderate fish consumption is associated with lower likelihood of developing Left Ventricular Systolic Dysfunction in acute coronary syndrome patients.
MedLine Citation:
PMID:  20492174     Owner:  NLM     Status:  MEDLINE    
The aim of the present work was to evaluate the association between fish consumption and the development of left ventricular systolic dysfunction in patients who have had an acute coronary syndrome (ACS). During 2006 to 2009, 934 consecutive ACS patients were included in the study; 437 patients who developed LVSD, 347 male (64 +/- 13 y) and 90 female (71 +/- 12 y), and 497 patients with preserved systolic function, 388 male (62 +/- 12 y) and 109 female (66 +/- 12 y). Detailed information regarding their medical records, anthropometric data, physical activity, and smoking habits were recorded. Nutritional habits were assessed using a semiquantitative food-frequency questionnaire. Multi-adjusted analysis revealed that moderate fish consumption was associated with 53% (95% CI: 0.22 to 0.97) lower likelihood of developing left ventricular systolic dysfunction, compared to no/rare consumption, after adjustment for various confounding factors. Furthermore, moderate fish consumption was associated with lower values of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (P = 0.05) and oxidized LDL cholesterol (P = 0.02) in patients who did not develop left ventricular systolic dysfunction. Moderate fish consumption seems to offer significant protection against the development of systolic dysfunction in post ACS patients, merely attributed to its beneficial effect on oxidation process and endothelial function.
C-M Kastorini; C Chrysohoou; P Aggelopoulos; D Panagiotakos; C Pitsavos; C Stefanadis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H24-9     Citation Subset:  IM    
Dept. of Nutrition Science - Dietetics, Harokopio Univ., Athens, Greece.
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MeSH Terms
Acute Coronary Syndrome / complications,  physiopathology*
Aged, 80 and over
Middle Aged
Patient Selection
Stroke Volume
Systole / physiology
Ventricular Dysfunction, Left / epidemiology,  prevention & control*

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