Document Detail

Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers.
MedLine Citation:
PMID:  19943984     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.
David Vauzour; Emily J Houseman; Trevor W George; Giulia Corona; Roselyne Garnotel; Kim G Jackson; Christelle Sellier; Philippe Gillery; Orla B Kennedy; Julie A Lovegrove; Jeremy P E Spencer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-11-30
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-04-30     Revised Date:  2010-12-29    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1168-78     Citation Subset:  IM    
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK.
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MeSH Terms
Alcohol Drinking*
Cross-Over Studies
Endothelium, Vascular / drug effects,  physiology*
Flavonoids / pharmacology
Laser-Doppler Flowmetry
Matrix Metalloproteinase 9 / blood
Middle Aged
Oxidants / blood
Phenols / pharmacology,  urine
Single-Blind Method
Tissue Inhibitor of Metalloproteinases / blood
Vasodilation / drug effects,  physiology*
Young Adult
Grant Support
BB/E023185/1//Biotechnology and Biological Sciences Research Council; BB/F008953/1//Biotechnology and Biological Sciences Research Council; BB/G005702/1//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Flavonoids; 0/Oxidants; 0/Phenols; 0/Tissue Inhibitor of Metalloproteinases; 0/polyphenols; EC Metalloproteinase 9

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