| Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers. | |
MedLine Citation:
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PMID: 19943984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity. |
Authors:
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David Vauzour; Emily J Houseman; Trevor W George; Giulia Corona; Roselyne Garnotel; Kim G Jackson; Christelle Sellier; Philippe Gillery; Orla B Kennedy; Julie A Lovegrove; Jeremy P E Spencer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-11-30 |
Journal Detail:
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Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-04-30 Revised Date: 2010-12-29 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1168-78 Citation Subset: IM |
Affiliation:
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Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcohol Drinking* Cross-Over Studies Endothelium, Vascular / drug effects, physiology* Female Flavonoids / pharmacology Humans Iontophoresis Laser-Doppler Flowmetry Male Matrix Metalloproteinase 9 / blood Middle Aged Oxidants / blood Phenols / pharmacology, urine Single-Blind Method Tissue Inhibitor of Metalloproteinases / blood Vasodilation / drug effects, physiology* Wine* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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BB/E023185/1//Biotechnology and Biological Sciences Research Council; BB/F008953/1//Biotechnology and Biological Sciences Research Council; BB/G005702/1//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Oxidants; 0/Phenols; 0/Tissue Inhibitor of Metalloproteinases; 0/polyphenols; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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