| Models versus established knowledge in describing the functional morphology of the ventricular myocardium. | |
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MedLine Citation:
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PMID: 18598980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The myocytes comprising the ventricular mass are arranged so as to function in antagonistic fashion, the walls having the capacity to generate both constrictive and dilatory forces. This dualistic activity is organized on the basis of a site-specific morphologic pattern, permitting marked regional specificity for mural motion and providing a target for regional therapy. Diseased regions can be removed surgically without danger of jeopardizing the remaining healthy mural segments. The sensitivity of the intruding population of myocytes to positive and negative inotropic medication is markedly more pronounced than that of the prevailing tangentially aligned myocytes. This asymmetrical action of inotropes in the setting of global ventricular imbalance promotes the potential to restore constrictive as opposed to dilatory actions. |
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Authors:
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Paul P Lunkenheimer; Klaus Redmann; Peter Niederer; Peter Schmid; Morten Smerup; Jörg Stypmann; Sabine Däbritz; Kai Rothaus; Robert H Anderson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Heart failure clinics Volume: 4 ISSN: 1551-7136 ISO Abbreviation: - Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-10-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101231934 Medline TA: Heart Fail Clin Country: United States |
Other Details:
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Languages: eng Pagination: 273-88 Citation Subset: IM |
Affiliation:
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University of Münster, Münster, Germany. lunkenhe@uni-muenster.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diffusion Magnetic Resonance Imaging Fibrosis / physiopathology Heart Ventricles / anatomy & histology*, physiopathology Humans Models, Cardiovascular* Muscle Cells / physiology* Myocardial Contraction Myocardium* Ventricular Function* |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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