| Models of neurodegenerative disease - Alzheimer's anatomical and amyloid plaque imaging. | |
| | |
MedLine Citation:
|
PMID: 21874485 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Alzheimer's disease (AD) is an important social and economic issue for our societies. The development of therapeutics against this severe dementia requires assessing the effects of new drugs in animal models thanks to dedicated biomarkers. According to the amyloid cascade hypothesis, β-amyloid deposits are at the origin of most of the lesions associated with AD. These extracellular deposits are therefore one of the main targets in therapeutical strategies. Aβ peptides can be revealed histologically with specific dyes or antibodies, or by magnetic resonance microscopy (μMRI) that uses their association with iron as a source of signal. The microscopic size of the lesions necessitates the development of specific imaging protocols. Most protocols use T (2)-weighted sequences that reveal the aggregates as hypointense spots. This chapter describes histological methods that reveal amyloid plaques with specific stains and MR-imaging protocols for in vivo and ex vivo MR imaging of AD mice. |
| | |
Authors:
|
Alexandra Petiet; Benoit Delatour; Marc Dhenain |
Related Documents
:
|
17035045 - Eeg/(f)mri measurements at 7 tesla using a new eeg cap ("inkcap"). 19236945 - Clinical mri in children and adults with focal epilepsy: a critical review. 17507885 - Utility of computed tomography and selected mr sequences in the diagnostics of patients... 7976465 - Electroencephalography, computed tomography and violence ratings of male patients in a ... 7763365 - Biodegradation of phenol: a comparative study with and without applying magnetic fields. 3060755 - Ultrasonography in hereditary degenerative diseases of the cerebral white matter in inf... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Methods in molecular biology (Clifton, N.J.) Volume: 771 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-08-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 293-308 Citation Subset: IM |
Affiliation:
|
CNRS, URA 2210, Fontenay aux Roses, France, alexandra.petiet@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Volumetry and other quantitative measurements to assess the rodent brain.
Next Document: MRI in animal models of psychiatric disorders.