Document Detail

Models for narcolepsy with cataplexy drug discovery.
MedLine Citation:
PMID:  22468916     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Narcolepsy is a chronic sleep disorder, characterized by a disrupted nocturnal sleep, excessive daytime sleepiness (EDS) and symptoms of dissociated rapid eye movement (REM) sleep. These symptoms are often disabling, confining the patients to a life-long pharmacologic symptomatic treatment. Nowadays, it is well known that narcolepsy results from alterations in the genes involved in the physiology of the orexin ligand or its receptor.
AREAS COVERED: This review recapitulates on the current approaches for treating narcolepsy with cataplexy and the use of narcolepsy models in order to address different aspects of the disease.
EXPERT OPINION: Animal models are required for the study of human diseases when it is impractical or unethical to use humans; these models are useful for studying the underlying causes of a disease and are a common research tool for identifying potential drug targets. Current treatment for human narcolepsy is symptomatically based; interestingly, the existing approaches do not target the orexinergic circuit. The discovery of novel drug targets for treating narcolepsy remains the primary focus of study in sleep medicine research. New therapies will arise through the discovery of new animal models of narcolepsy, which will offer new insights into the understanding of its physiopathology.
Alberto K De la Herrán-Arita; René Drucker-Colín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-11
Journal Detail:
Title:  Expert opinion on drug discovery     Volume:  7     ISSN:  1746-045X     ISO Abbreviation:  Expert Opin Drug Discov     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-03     Completed Date:  2012-09-24     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101295755     Medline TA:  Expert Opin Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-64     Citation Subset:  IM    
Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México.
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MeSH Terms
Disease Models, Animal
Drug Design*
Drug Discovery / methods
Intracellular Signaling Peptides and Proteins / administration & dosage,  metabolism
Models, Biological
Molecular Targeted Therapy*
Narcolepsy / drug therapy*,  physiopathology
Neuropeptides / administration & dosage,  metabolism
Receptors, G-Protein-Coupled / metabolism
Receptors, Neuropeptide / metabolism
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Receptors, G-Protein-Coupled; 0/Receptors, Neuropeptide; 0/orexin receptors; 0/orexins

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