Document Detail


Models of experimental evolution: the role of genetic chance and selective necessity.
MedLine Citation:
PMID:  11063715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a theoretical framework within which to analyze the results of experimental evolution. Rapidly evolving organisms such as viruses, bacteria, and protozoa can be induced to adapt to laboratory conditions on very short human time scales. Artificial adaptive radiation is characterized by a list of common observations; we offer a framework in which many of these repeated questions and patterns can be characterized analytically. We allow for stochasticity by including rare mutations and bottleneck effects, demonstrating how these increase variability in the evolutionary trajectory. When the product Np, the population size times the per locus error rate, is small, the rate of evolution is limited by the chance occurrence of beneficial mutations; when Np is large and selective pressure is strong, the rate-limiting step is the waiting time while existing beneficial mutations sweep through the population. We derive the rate of divergence (substitution rate) and rate of fitness increase for the case when Np is large and illustrate our approach with an application to an experimental data set. A minimal assumption of independent additive fitness contributions provides a good fit to the experimental evolution of the bacteriophage phiX174.
Authors:
L M Wahl; D C Krakauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  156     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2001-01-04     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1437-48     Citation Subset:  IM    
Affiliation:
Institute for Advanced Study, Princeton, New Jersey 08540, USA. lmw@scratchy.dhis.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / genetics
Directed Molecular Evolution*
Eukaryota / genetics
Evolution*
Models, Genetic*
Models, Statistical*
Mutation
Stochastic Processes
Viruses / genetics
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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