| Modelling of tumour repopulation after chemotherapy. | |
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MedLine Citation:
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PMID: 20652783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While repopulation is a clinically observed phenomenon after radiotherapy, repopulation of tumour cells between cycles of chemotherapy is usually a neglected factor in cancer treatment. As the effect of both radiotherapy and chemotherapy on tumour cells is the same (attack on cancer cells), the response of the tumour to injury and cell loss from the two treatment methods should be similar, including repopulation. Cell recruitment is known to be a possible mechanism responsible for tumour regrowth after radiotherapy. The literature data regarding mechanisms of repopulation after chemotherapy is very limited. The current paper employs a Monte Carlo modelling approach to implement the pharmacokinetics of a widely used drug (cisplatin) into a previously developed virtual head and neck tumour and to study the effect of cisplatin on tumour regression and regrowth during treatment. The mechanism of cell recruitment was modelled by releasing various percentages (5-50%) of quiescent cells into the mitotic cycle after each chemotherapy cell kill. The onset of repopulation was also simulated, with both immediate onset and late onset of cell recruitment. Repopulation during chemotherapy, if occurring, is a highly potent phenomenon, similar to drug resistance, therefore it should not be neglected during treatment. |
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Authors:
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Loredana Marcu; Eva Bezak |
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Publication Detail:
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Type: Journal Article Date: 2010-07-23 |
Journal Detail:
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Title: Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine Volume: 33 ISSN: 0158-9938 ISO Abbreviation: Australas Phys Eng Sci Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8208130 Medline TA: Australas Phys Eng Sci Med Country: Australia |
Other Details:
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Languages: eng Pagination: 265-70 Citation Subset: IM |
Affiliation:
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School of Chemistry and Physics, University of Adelaide, Adelaide, Australia. loredana.marcu@fizicaoradea.ro |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacokinetics, therapeutic use Cell Cycle / drug effects Cell Death / drug effects Cell Line, Tumor Cisplatin / pharmacokinetics, therapeutic use Head and Neck Neoplasms / drug therapy, pathology Humans Leukemia L1210 / drug therapy, pathology Mice Models, Biological* Monte Carlo Method Neoplasms, Experimental / drug therapy*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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