Document Detail

Modelling of tumour repopulation after chemotherapy.
MedLine Citation:
PMID:  20652783     Owner:  NLM     Status:  MEDLINE    
While repopulation is a clinically observed phenomenon after radiotherapy, repopulation of tumour cells between cycles of chemotherapy is usually a neglected factor in cancer treatment. As the effect of both radiotherapy and chemotherapy on tumour cells is the same (attack on cancer cells), the response of the tumour to injury and cell loss from the two treatment methods should be similar, including repopulation. Cell recruitment is known to be a possible mechanism responsible for tumour regrowth after radiotherapy. The literature data regarding mechanisms of repopulation after chemotherapy is very limited. The current paper employs a Monte Carlo modelling approach to implement the pharmacokinetics of a widely used drug (cisplatin) into a previously developed virtual head and neck tumour and to study the effect of cisplatin on tumour regression and regrowth during treatment. The mechanism of cell recruitment was modelled by releasing various percentages (5-50%) of quiescent cells into the mitotic cycle after each chemotherapy cell kill. The onset of repopulation was also simulated, with both immediate onset and late onset of cell recruitment. Repopulation during chemotherapy, if occurring, is a highly potent phenomenon, similar to drug resistance, therefore it should not be neglected during treatment.
Loredana Marcu; Eva Bezak
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Publication Detail:
Type:  Journal Article     Date:  2010-07-23
Journal Detail:
Title:  Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine     Volume:  33     ISSN:  0158-9938     ISO Abbreviation:  Australas Phys Eng Sci Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208130     Medline TA:  Australas Phys Eng Sci Med     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
School of Chemistry and Physics, University of Adelaide, Adelaide, Australia.
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MeSH Terms
Antineoplastic Agents / pharmacokinetics,  therapeutic use
Cell Cycle / drug effects
Cell Death / drug effects
Cell Line, Tumor
Cisplatin / pharmacokinetics,  therapeutic use
Head and Neck Neoplasms / drug therapy,  pathology
Leukemia L1210 / drug therapy,  pathology
Models, Biological*
Monte Carlo Method
Neoplasms, Experimental / drug therapy*,  pathology*
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

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