| Modelling treatment-effect heterogeneity in randomized controlled trials of complex interventions (psychological treatments). | |
| | |
MedLine Citation:
|
PMID: 17476649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We describe instrumental variable (IV) methods for the estimation of the 'dose'-response effects of psychological interventions in randomized controlled trials in which there is variability in the patients' adherence to the allocated therapy (that is, variability in the actual number of sessions of therapy attended) and also variability in the strength of the therapeutic alliance between patients and their therapists. The effect of the therapy on outcome is assumed to be a function of both the number of sessions attended and the strength of the therapeutic alliance, with no intervention effects in the absence of any sessions attended (an exclusion restriction) and the effect of the strength of the alliance being represented by a multiplicative term (interaction) in the treatment-effect model. The IV methods that are described allow for: (a) hidden confounding between sessions, alliance and outcome; (b) measurement errors in the alliance; and (c) that alliance is only measured in those receiving treatment. Three two-stage estimation procedures are illustrated, and their equivalence demonstrated, through Monte Carlo simulation and analysis of the results of an actual trial. |
| | |
Authors:
|
Graham Dunn; Richard Bentall |
Related Documents
:
|
12466679 - A comparison of clonidine and buprenorphine in the outpatient treatment of opiate withd... 19563559 - Feasibility and validity of low-budget telephonic follow-up interviews in routine outco... 8885439 - A descriptive-exploratory study of outcome and some biopsychosocial characteristics of ... 9922559 - Cognitive behavior group therapy for body dysmorphic disorder: a case series. 22342199 - Treatment of bankart lesions in traumatic anterior instability of the shoulder: a rando... 16343809 - One year outcomes for heroin dependence: findings from the australian treatment outcome... 15977019 - Acquired uterine vascular malformations: radiological and clinical outcome after transc... 11552189 - Manipulation under anesthesia for frozen shoulder with and without steroid injection. 20622749 - Hemivertebra resection for congenital scoliosis in young children: comparison of clinic... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Statistics in medicine Volume: 26 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-10-08 Completed Date: 2008-01-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8215016 Medline TA: Stat Med Country: England |
Other Details:
|
Languages: eng Pagination: 4719-45 Citation Subset: IM |
Affiliation:
|
Biostatistics Group, Division of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, U.K. graham.dunn@manchester.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms* Cognitive Therapy / methods*, statistics & numerical data Great Britain Humans Monte Carlo Method Patient Compliance* / statistics & numerical data Schizophrenia / therapy Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inferences on the mean response in a log-regression model: the generalized variable approach.
Next Document: Constructing multiple test procedures for partially ordered hypothesis sets.