Document Detail


Modelling and simulation of substrate elasticity sensing in stem cells.
MedLine Citation:
PMID:  21516529     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Recently, we have developed a multiscale soft matter cell model aiming at improving the understanding of mechanotransduction mechanism of stem cells, which is responsible for information exchange between cells and their extracellular environment. In this paper, we report the preliminary results of our research on multiscale modelling and simulation of soft contact and adhesion of stem cells. The proposed multiscale soft matter cell model may be used to model soft contact and adhesion between cells and their extracellular substrates. To the authors' best knowledge, this may be the first time that a soft matter model has been developed for cell contact and adhesion. Moreover, we have developed and implemented a Lagrange-type meshfree Galerkin formulation and related computational algorithms for the proposed cell model. Comparison study with experimental data has been conducted to validate the parameters of the cell model. By using the soft matter cell model, we have simulated the soft adhesive contact process between cells and extracellular substrates. The simulation shows that the cell can sense substrate elasticity by responding it in different manners from cell spreading to cell contact configuration and molecular conformation changes.
Authors:
Xiaowei Zeng; Shaofan Li
Related Documents :
12817479 - Quantification of elastase-like activity in 13 human cancer cell lines and in an immort...
21472999 - Tracking stem cells using magnetic nanoparticles.
312899 - Isolation and immunological characterization of a major surface glycoprotein (gp54) pre...
8133779 - Response of ataxia telangiectasia cells to restriction endonuclease induced dna double-...
21167769 - Cancer stem cell traits in squamospheres derived from primary head and neck squamous ce...
2475259 - A novel monoclonal antibody, 1b3.1, binds to a new epitope of the vla-1 molecule.
2453219 - Cardiotoxin from cobra venom increases the level of phosphatidylinositol 4-monophosphat...
9135669 - Immunohistochemical localization of riboflavin carrier protein in testicular cells of m...
8523459 - The role of lipid peroxidation in menadione-mediated toxicity in cardiomyocytes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  14     ISSN:  1476-8259     ISO Abbreviation:  Comput Methods Biomech Biomed Engin     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-58     Citation Subset:  IM    
Affiliation:
Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An Eulerian/XFEM formulation for the large deformation of cortical cell membrane.
Next Document:  Simulations of the contractile cycle in cell migration using a bio-chemical-mechanical model.