| Modelling of pulsatile blood flow in arterial trees of retinal vasculature. | |
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MedLine Citation:
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PMID: 21044855 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The paper presents a numerical investigation of the pulsatile blood flow in the detailed arterial vasculatures of a mouse retina using the mathematical model based on frequency domain incorporating an appropriate outlet boundary impedance at the end of the terminal vessels of the arterial trees. The viscosity in the vessels was evaluated considering the Fahraeus-Lindqvist effect, the plasma skimming effect and in vivo viscosity effect in the microcirculation. Comparative studies of the pulsatile circulation were carried out for cases of rigid vessels, constant viscosity, zero and non-zero outlet boundary impedances. In addition, the dependence of the oscillating input impedance at the inlet of the arterial trees on angular frequencies of the oscillation and vessel elasticises was also studied. The study shows that the pressure wave continues in the pre-capillary vessels throughout the retina. In elastic vessels, the amplitude of oscillatory velocity and wall shear stress in larger vessels and in vessels at the periphery region of the retina is amplified. The pulsatile blood flow is significantly influenced by the outlet boundary (or load) impedance which simulates the effect of the capillary and venous vasculatures. The oscillating input impedance at the inlet of the arterial trees is also found to be dependent on the angular frequency and the Young modulus of the vessel segment. Insights into the potential variations of the dynamic responses of the system under retinal pathological condition of arteriosclerosis may be inferred from the findings of the present study. |
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Authors:
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P Ganesan; S He; H Xu |
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Publication Detail:
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Type: Journal Article Date: 2010-11-01 |
Journal Detail:
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Title: Medical engineering & physics Volume: 33 ISSN: 1873-4030 ISO Abbreviation: Med Eng Phys Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422753 Medline TA: Med Eng Phys Country: England |
Other Details:
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Languages: eng Pagination: 810-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Engineering, University of Aberdeen, Fraser Noble Building, Aberdeen, AB24 3UE, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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