| Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs. | |
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MedLine Citation:
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PMID: 20361838 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This work elaborates on the effects of cytotoxic lymphocytes (CTLs) and other immune mechanisms in determining whether a TB-infected individual will develop active or latent TB. It answers one intriguing question: why do individuals infected with Mycobacterium tuberculosis (Mtb) experience different clinical outcomes? In addressing this question, we have developed a model that captures the effects of CTLs and the combined effects of CD4+ helper T cells (Th1 and Th2) immune response mechanisms to TB infection. The occurrence of active or latent infection is shown to depend on a number of factors that include effector function and levels of CTLs. We use the model to predict disease progression scenarios, including primary, latency or clearance. Model analysis shows that occurrence of active disease is much attributed to the Mtb pathogen ability to persist outside the intracellular environment and that high levels of CTLs result in latent TB, while low levels of CTLs result in active TB. This is attributed to the CTLs' ability to directly kill infected macrophages and the bacteria inside the infected macrophages. The study suggests directions for further basic studies and potential new treatment strategies. |
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Authors:
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Gesham Magombedze; Winston Garira; Eddie Mwenje |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mathematical biosciences and engineering : MBE Volume: 3 ISSN: 1547-1063 ISO Abbreviation: Math Biosci Eng Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2010-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197794 Medline TA: Math Biosci Eng Country: United States |
Other Details:
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Languages: eng Pagination: 661-82 Citation Subset: - |
Affiliation:
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Department of Applied Mathematics, National University of Science and Technology, PO Box AC939 Ascot, Bulawayo, Zimbabwe. gmagombedze@nust.ac.zw. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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