Document Detail

Modelling the effect of non-uniform radon progeny activities on transformation frequencies in human bronchial airways.
MedLine Citation:
PMID:  16682395     Owner:  NLM     Status:  MEDLINE    
The effects of radiological and morphological source heterogeneities in straight and Y-shaped bronchial airways on hit frequencies and microdosimetric quantities in epithelial cells have been investigated previously. The goal of the present study is to relate these physical quantities to transformation frequencies in sensitive target cells and to radon-induced lung cancer risk. Based on an effect-specific track length model, computed linear energy transfer (LET) spectra were converted to corresponding transformation frequencies for different activity distributions and source-target configurations. Average transformation probabilities were considerably enhanced for radon progeny accumulations and target cells at the carinal ridge, relative to uniform activity distributions and target cells located along the curved and straight airway portions at the same exposure level. Although uncorrelated transformation probabilities produce a linear dose-effect relationship, correlated transformations first increase depending on the LET, but then decrease significantly when exceeding a defined number of hits or cumulative exposure level.
H Fakir; W Hofmann; I Aubineau-Laniece
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-08
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  121     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-35     Citation Subset:  IM    
Division of Physics and Biophysics, Department of Material Science, University of Salzburg, Salzburg, Austria.
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MeSH Terms
Air Pollutants, Radioactive / analysis*
Alpha Particles
Bronchi / metabolism*,  radiation effects
Cell Nucleus / metabolism,  radiation effects*
Computer Simulation
Linear Energy Transfer
Models, Biological*
Monte Carlo Method
Radiometry / methods*
Radon Daughters / analysis*
Respiratory Mucosa / metabolism,  radiation effects*
Reg. No./Substance:
0/Air Pollutants, Radioactive; 0/Radon Daughters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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