| Modelling the effect of non-uniform radon progeny activities on transformation frequencies in human bronchial airways. | |
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MedLine Citation:
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PMID: 16682395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of radiological and morphological source heterogeneities in straight and Y-shaped bronchial airways on hit frequencies and microdosimetric quantities in epithelial cells have been investigated previously. The goal of the present study is to relate these physical quantities to transformation frequencies in sensitive target cells and to radon-induced lung cancer risk. Based on an effect-specific track length model, computed linear energy transfer (LET) spectra were converted to corresponding transformation frequencies for different activity distributions and source-target configurations. Average transformation probabilities were considerably enhanced for radon progeny accumulations and target cells at the carinal ridge, relative to uniform activity distributions and target cells located along the curved and straight airway portions at the same exposure level. Although uncorrelated transformation probabilities produce a linear dose-effect relationship, correlated transformations first increase depending on the LET, but then decrease significantly when exceeding a defined number of hits or cumulative exposure level. |
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Authors:
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H Fakir; W Hofmann; I Aubineau-Laniece |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-08 |
Journal Detail:
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Title: Radiation protection dosimetry Volume: 121 ISSN: 0144-8420 ISO Abbreviation: Radiat Prot Dosimetry Publication Date: 2006 |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109958 Medline TA: Radiat Prot Dosimetry Country: England |
Other Details:
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Languages: eng Pagination: 221-35 Citation Subset: IM |
Affiliation:
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Division of Physics and Biophysics, Department of Material Science, University of Salzburg, Salzburg, Austria. hatim.fakir@sbg.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants, Radioactive
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analysis* Alpha Particles Bronchi / metabolism*, radiation effects Cell Nucleus / metabolism, radiation effects* Computer Simulation Humans Linear Energy Transfer Models, Biological* Monte Carlo Method Radiometry / methods* Radon Daughters / analysis* Respiratory Mucosa / metabolism, radiation effects* |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Radioactive; 0/Radon Daughters |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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