Document Detail

Modelling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits.
MedLine Citation:
PMID:  11403709     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the response of the spinal cord of experimental animals to homogeneous irradiation, the main purpose being to propose a new version of the Critical Volume Normal Tissue Complication Probability (NTCP) model, incorporating spatial correlation between damaged functional subunits (FSU). METHOD: The standard Critical Volume NTCP model and its modified version, the Contiguous Damage model promoted here, are described in mathematical terms. Also, a fiber-like structure of the spinal cord is considered, which is a more complex structure than the standard Critical Volume NTCP model assumes. It is demonstrated that the Contiguous Damage model predicts different responses to two-segment irradiation and to single-segment irradiation to the same combined length as observed in experiments on rats, a result that cannot be described by the standard Critical Volume NTCP model. RESULTS AND CONCLUSIONS: Both the Critical Volume model and the Contiguous Damage model, are fitted to two sets of canine spinal cord radiation data corresponding to two different fractionation regimes of irradiation. Whole-organ irradiation as well as partial irradiation to different lengths are considered, allowing the investigation of dose-volume effects. Formal goodness-of-fit investigation shows that both models fit the canine spinal cord data equally well.
N Stavreva; A Niemierko; P Stavrev; M Goitein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of radiation biology     Volume:  77     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-07-12     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM; S    
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit St, Boston, MA 02114, USA.
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MeSH Terms
Data Interpretation, Statistical
Dose-Response Relationship, Radiation
Models, Biological*
Radiation Injuries, Experimental / etiology
Spinal Cord / anatomy & histology,  radiation effects*
Spinal Cord Injuries / etiology
Grant Support

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