| Modelling the controls of the eukaryotic cell cycle. | |
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MedLine Citation:
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PMID: 14641104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression. |
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Authors:
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B Novák; J J Tyson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biochemical Society transactions Volume: 31 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1526-9 Citation Subset: IM |
Affiliation:
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Molecular Network Dynamics Research Group of Hungarian Academy of Sciences and Budapest University of Technology and Economics, 1521 Budapest, Gellért tér 4, Hungary. bnovak@mail.bme.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Eukaryotic Cells Models, Biological* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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