Document Detail

Modelling control measures to reduce the impact of pandemic influenza among schoolchildren.
MedLine Citation:
PMID:  17850689     Owner:  NLM     Status:  MEDLINE    
We coupled the Wells-Riley equation and the susceptible-exposed-infected-recovery (SEIR) model to quantify the impact of the combination of indoor air-based control measures of enhanced ventilation and respiratory masking in containing pandemic influenza within an elementary school. We integrated indoor environmental factors of a real elementary school and aetiological characteristics of influenza to estimate the age-specific risk of infection (P) and basic reproduction number (R(0)). We combined the enhanced ventilation rates of 0.5, 1, 1.5, and 2/h and respiratory masking with 60%, 70%, 80%, and 95% efficacies, respectively, to predict the reducing level of R0. We also took into account the critical vaccination coverage rate among schoolchildren. Age-specific P and R(0) were estimated respectively to be 0.29 and 16.90; 0.56 and 16.11; 0.59 and 12.88; 0.64 and 16.09; and 0.07 and 2.80 for five age groups 4-6, 7-8, 9-10, 11-12, and 25-45 years, indicating pre-schoolchildren have the highest transmission potential. We conclude that our integrated approach, employing the mechanism of transmission of indoor respiratory infection, population-dynamic transmission model, and the impact of infectious control programmes, is a powerful tool for risk profiling prediction of pandemic influenza among schoolchildren.
S-C Chen; C-M Liao
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Publication Detail:
Type:  Journal Article     Date:  2007-09-13
Journal Detail:
Title:  Epidemiology and infection     Volume:  136     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2008-09-04     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1035-45     Citation Subset:  IM    
Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan, ROC.
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MeSH Terms
Air Microbiology*
Air Pollution, Indoor / analysis
Child, Preschool
Community-Acquired Infections / epidemiology*,  prevention & control,  transmission,  virology*
Influenza Vaccines
Influenza, Human / epidemiology*,  prevention & control,  transmission,  virology*
Models, Statistical
Risk Assessment
Taiwan / epidemiology
Reg. No./Substance:
0/Influenza Vaccines

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