| Modelling carotid artery adaptations to dynamic alterations in pressure and flow over the cardiac cycle. | |
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MedLine Citation:
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PMID: 20484365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Motivated by recent clinical and laboratory findings of important effects of pulsatile pressure and flow on arterial adaptations, we employ and extend an established constrained mixture framework of growth (change in mass) and remodelling (change in structure) to include such dynamical effects. New descriptors of cell and tissue behavior (constitutive relations) are postulated and refined based on new experimental data from a transverse aortic arch banding model in the mouse that increases pulsatile pressure and flow in one carotid artery. In particular, it is shown that there was a need to refine constitutive relations for the active stress generated by smooth muscle, to include both stress- and stress rate-mediated control of the turnover of cells and matrix and to account for a cyclic stress-mediated loss of elastic fibre integrity and decrease in collagen stiffness in order to capture the reported evolution, over 8 weeks, of luminal radius, wall thickness, axial force and in vivo axial stretch of the hypertensive mouse carotid artery. We submit, therefore, that complex aspects of adaptation by elastic arteries can be predicted by constrained mixture models wherein individual constituents are produced or removed at individual rates and to individual extents depending on changes in both stress and stress rate from normal values. |
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Authors:
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L Cardamone; A Valentín; J F Eberth; J D Humphrey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-19 |
Journal Detail:
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Title: Mathematical medicine and biology : a journal of the IMA Volume: 27 ISSN: 1477-8602 ISO Abbreviation: Math Med Biol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-07-15 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101182345 Medline TA: Math Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 343-71 Citation Subset: IM |
Affiliation:
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Dipartimento di Ingegneria Civile, Università di Salerno, 84084 Fisciano, Italy. lcardamo@unisa.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Biomechanics Blood Flow Velocity / physiology* Blood Pressure / physiology* Carotid Artery, Common / pathology, physiology*, physiopathology* Collagen / metabolism Computer Simulation Elasticity Elastin / metabolism Extracellular Matrix / physiology Hypertension / pathology, physiopathology Mice Models, Cardiovascular* Muscle, Smooth, Vascular / physiology, physiopathology Myocardial Contraction / physiology* Pulsatile Flow / physiology Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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HL-80415/HL/NHLBI NIH HHS; HL-86418/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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