Document Detail

Modelling binary data from a three-period cross-over trial.
MedLine Citation:
PMID:  3659665     Owner:  NLM     Status:  MEDLINE    
A new method of analysing binary data from a three-treatment, three-period cross-over trial is described. This method is based on a log-linear model and mirrors the analysis of continuous data. It is an extension of the method we introduced recently for the analysis of binary data from a two-treatment, two-period cross-over trial. We illustrate our method using data from a trial which compared two analgesics and a placebo for the relief of primary dysmenorrhea.
B Jones; M G Kenward
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Statistics in medicine     Volume:  6     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1987 Jul-Aug
Date Detail:
Created Date:  1987-11-05     Completed Date:  1987-11-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-64     Citation Subset:  IM    
Mathematical Institute, The University, Canterbury, Kent, U.K.
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MeSH Terms
Analgesics / therapeutic use
Clinical Trials as Topic / methods*
Data Interpretation, Statistical*
Dysmenorrhea / drug therapy
Models, Biological
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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