Document Detail


Modelling adolescent blood pressure patterns and their prediction of adult pressures.
MedLine Citation:
PMID:  1742427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tracking of blood pressure in adolescent boys is investigated using a mathematical model that corresponds to progression along a constant percentile. A more general analysis, based on the method of principal components, is also proposed that determines various alternative tracks or patterns that are most prevalent in the longitudinal blood pressure data. The degree of tracking along a constant percentile curve for systolic pressure was moderately high, as evidenced by a tracking index of .78 explaining 81% of the variance, but less strong for diastolic (tracking index of .60) where tracking along a percentile explained 66% of the variance. The value of the more general analysis of blood pressure patterns may lie in the assessment of adolescent risk factors for elevated adult blood pressure. Using adolescent patterns determined by either statistical model, adult systolic at age 38 was predicted (R2 = .22) by the concept of a systolic fixed percentile curve in adolescence, and similarly for diastolic (R2 = .21). However, the more general analysis based on longitudinal principal components further suggests that boys who have a larger than usual systolic peak at age 14 years, which is near the time of the adolescent physical growth spurt in these boys, may be more likely to have higher systolic pressures at age 38. Because the adult data were incomplete and highly unbalanced, these findings were obtained using random-effects models for longitudinal data.
Authors:
C S Berkey; N M Laird; I Valadian; J Gardner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biometrics     Volume:  47     ISSN:  0006-341X     ISO Abbreviation:  Biometrics     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-01-14     Completed Date:  1992-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1005-18     Citation Subset:  IM    
Affiliation:
Harvard University, School of Dental Medicine, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Adolescent / physiology*
Adult
Blood Pressure*
Child
Diastole
Female
Humans
Infant, Newborn
Longitudinal Studies
Male
Mathematics
Models, Statistical
Pregnancy
Prognosis
Sex Characteristics
Systole
Grant Support
ID/Acronym/Agency:
GM 29745/GM/NIGMS NIH HHS; HS 05708/HS/AHRQ HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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