Document Detail

Modelling of Ca2+-activated chloride current in tracheal smooth muscle cells.
MedLine Citation:
PMID:  11804240     Owner:  NLM     Status:  MEDLINE    
Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl- current (I(ClCa)) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model I(ClCa) in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple binding site activation by calcium. In order to validate the model, a combination of equations, used to mimic [Ca2+]i response to ACh stimulation, were incorporated into the model. The results indicate that the model developed in this article accounts for experimental recordings and electrophysiological characteristics of this current in airway smooth muscle cells, with parameter values consistent with those calculated from experimental data. Such a model may thus be used to predict I(ClCa) functioning, though additional experimental data from airway myocytes would be useful to more accurately determine some parameter values of the model.
E Roux; P J Noble; J M Hyvelin; D Noble
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biotheoretica     Volume:  49     ISSN:  0001-5342     ISO Abbreviation:  Acta Biotheor.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421520     Medline TA:  Acta Biotheor     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
Laboratoire de Physiologie cellulaire respiratoire, EMI 9937, Université Victor, Segalen Bordeaux 2, France.
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MeSH Terms
Acetylcholine / physiology*
Airway Resistance / physiology
Calcium / physiology*
Cells, Cultured
Chloride Channels / physiology*
Computer Simulation*
Membrane Potentials / physiology
Models, Theoretical*
Muscle, Smooth / cytology*
Trachea / cytology*
Reg. No./Substance:
0/Chloride Channels; 51-84-3/Acetylcholine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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