Document Detail


Modelled temperature-dependent excitability behaviour of a single ranvier node for a human peripheral sensory nerve fibre.
MedLine Citation:
PMID:  19066936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine whether the Hodgkin-Huxley model for unmyelinated nerve fibres could be modified to predict excitability behaviour at Ranvier nodes. Only the model parameters were modified to those of human, with the equations left unaltered. A model of a single Ranvier node has been developed as part of a larger model to describe excitation behaviour in a generalised human peripheral sensory nerve fibre. Parameter values describing the ionic and leakage conductances, corresponding equilibrium potentials, resting membrane potential and membrane capacitance of the original Hodgkin-Huxley model were modified to reflect the corresponding parameter values for human. Parameter temperature dependence was included. The fast activating potassium current kinetics were slowed down to represent those of a slow activating and deactivating potassium current, which do not inactivate. All calculations were performed in MATLAB. Action potential shape and amplitude were satisfactorily predicted at 20, 25 and 37 degrees C, and were not influenced by activation or deactivation of the slow potassium current. The calculated chronaxie time constant was 65.5 micros at 37 degrees C. However, chronaxie times were overestimated at temperatures lower than body temperature.
Authors:
Jacoba E Smit; Tania Hanekom; Johan J Hanekom
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-09
Journal Detail:
Title:  Biological cybernetics     Volume:  100     ISSN:  1432-0770     ISO Abbreviation:  Biol Cybern     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-17     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502533     Medline TA:  Biol Cybern     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  IM    
Affiliation:
Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Humans
Ion Channels / metabolism
Mathematics
Membrane Potentials / physiology*
Models, Neurological*
Nerve Fibers / physiology*
Potassium / metabolism
Ranvier's Nodes / physiology*
Sensory Receptor Cells / physiology*
Software
Temperature*
Chemical
Reg. No./Substance:
0/Ion Channels; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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