| Modelled temperature-dependent excitability behaviour of a single ranvier node for a human peripheral sensory nerve fibre. | |
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MedLine Citation:
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PMID: 19066936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine whether the Hodgkin-Huxley model for unmyelinated nerve fibres could be modified to predict excitability behaviour at Ranvier nodes. Only the model parameters were modified to those of human, with the equations left unaltered. A model of a single Ranvier node has been developed as part of a larger model to describe excitation behaviour in a generalised human peripheral sensory nerve fibre. Parameter values describing the ionic and leakage conductances, corresponding equilibrium potentials, resting membrane potential and membrane capacitance of the original Hodgkin-Huxley model were modified to reflect the corresponding parameter values for human. Parameter temperature dependence was included. The fast activating potassium current kinetics were slowed down to represent those of a slow activating and deactivating potassium current, which do not inactivate. All calculations were performed in MATLAB. Action potential shape and amplitude were satisfactorily predicted at 20, 25 and 37 degrees C, and were not influenced by activation or deactivation of the slow potassium current. The calculated chronaxie time constant was 65.5 micros at 37 degrees C. However, chronaxie times were overestimated at temperatures lower than body temperature. |
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Authors:
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Jacoba E Smit; Tania Hanekom; Johan J Hanekom |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-09 |
Journal Detail:
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Title: Biological cybernetics Volume: 100 ISSN: 1432-0770 ISO Abbreviation: Biol Cybern Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-17 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502533 Medline TA: Biol Cybern Country: Germany |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Affiliation:
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Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Ion Channels / metabolism Mathematics Membrane Potentials / physiology* Models, Neurological* Nerve Fibers / physiology* Potassium / metabolism Ranvier's Nodes / physiology* Sensory Receptor Cells / physiology* Software Temperature* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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