| Modeling of thermal effects in antivascular ultrasound therapy. | |
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MedLine Citation:
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PMID: 22280615 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Antivascular ultrasound consisting of low-intensity sonication in the presence of circulating microbubbles of an ultrasound contrast agent has been demonstrated to disrupt blood flow in solid cancers. In this study a mathematical framework is described for the microbubble-induced heating that occurs during antivascular ultrasound. Biological tissues are modeled as a continuum of microbubble-filled vasculature, cells, and interstitial fluids with compressibility equal to the sum of the compressibility of each component. The mathematical simulations show that the absorption of ultrasound waves by viscous damping of the microbubble oscillations induced significant local heating of the tissue vasculature. The extent and the rate of temperature increase not only depends on the properties of the microbubbles and the sonication parameters but is also influenced markedly by the blood flow. Slow flow conditions lead to higher tissue temperatures due to a stronger interaction between microbubbles and ultrasound and reduced heat dissipation. Because tumors have slower blood flow than healthy tissue, the microbubble-induced ultrasound antivascular therapy is likely to affect cancerous tissue more extensively than healthy tissue, providing a way to selectively target the vasculature of cancers. |
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Authors:
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Benjamin J Levenback; Chandra M Sehgal; Andrew K W Wood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 131 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 540 Citation Subset: IM |
Affiliation:
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Department of Radiology, School of Medicine, University of Pennsylvania, 1 Silverstein, 3400 Spruce Street, Philadelphia, Pennsylvania 19104. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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