| Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation. | |
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MedLine Citation:
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PMID: 11717534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Consequences of synaptic plasticity in the lamprey spinal CPG are analyzed by means of simulations. This is motivated by the effects substance P (a tachykinin) and serotonin (5-hydroxytryptamin; 5-HT) have on synaptic transmission in the locomotor network. Activity-dependent synaptic depression and potentiation have recently been shown experimentally using paired intracellular recordings. Although normally activity-dependent plasticity presumably does not contribute to the patterning of network activity, this changes in the presence of the neuromodulators substance P and 5-HT, which evoke significant plasticity. Substance P can induce a faster and larger depression of inhibitory connections but potentiation of excitatory inputs, whereas 5-HT induces facilitation of both inhibitory and excitatory inputs. Changes in the amplitude of the first postsynaptic potential are also seen. These changes could thus be a potential mechanism underlying the modulatory role these substances have on the rhythmic network activity. The aim of the present study has been to implement the activity dependent synaptic depression and facilitation induced by substance P and 5-HT into two alternative models of the lamprey spinal locomotor network, one relying on reciprocal inhibition for bursting and one in which each hemicord is capable of oscillations. The consequences of the plasticity of inhibitory and excitatory connections are then explored on the network level. In the intact spinal cord, tachykinins and 5-HT, which can be endogenously released, increase and decrease the frequency of the alternating left-right burst pattern, respectively. The frequency decreasing effect of 5-HT has previously been explained based on its conductance decreasing effect on K(Ca) underlying the postspike afterhyperpolarization (AHP). The present simulations show that short-term synaptic plasticity may have strong effects on frequency regulation in the lamprey spinal CPG. In the network model relying on reciprocal inhibition, the observed effects substance P and 5-HT have on network behavior (i.e., a frequency increase and decrease respectively) can to a substantial part be explained by their effects on the total extent and time dynamics of synaptic depression and facilitation. The cellular effects of these substances will in the 5-HT case further contribute to its network effect. |
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Authors:
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A Kozlov; J H Kotaleski; E Aurell; S Grillner; A Lansner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of computational neuroscience Volume: 11 ISSN: 0929-5313 ISO Abbreviation: J Comput Neurosci Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-11-21 Completed Date: 2002-02-01 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9439510 Medline TA: J Comput Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 183-200 Citation Subset: IM |
Affiliation:
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Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden. akoslov@nada.kth.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology Animals Biological Clocks / drug effects, physiology Excitatory Postsynaptic Potentials / drug effects, physiology Functional Laterality / drug effects, physiology Interneurons / drug effects, physiology Lampreys / anatomy & histology, metabolism Locomotion / drug effects, physiology* Models, Animal Models, Neurological Motor Neurons / drug effects, physiology Nerve Net / cytology, drug effects, metabolism* Neural Inhibition / drug effects, physiology Neural Networks (Computer) Neuronal Plasticity / drug effects, physiology* Receptors, AMPA / drug effects, physiology Receptors, N-Methyl-D-Aspartate / drug effects, physiology Serotonin / pharmacology, physiology* Spinal Cord / cytology, drug effects, metabolism* Substance P / pharmacology, physiology* Synapses / drug effects, metabolism Synaptic Transmission / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 33507-63-0/Substance P; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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