Document Detail


Modeling scattering from cells and biological structures.
MedLine Citation:
PMID:  18529319     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The goal of ultrasonic tissue characterization is to extract information over and above the information conventionally displayed on imaging instruments which is typically the backscatter strength (B-mode image). The driving hypothesis of our work is that as the ultrasound wavelength approaches the size of a cell, the backscatter characteristics become more sensitive to the cells' physical attributes (size, structure, and composition) and changes in the cell structure due to therapeutic intervention. A better understanding of the interaction of acoustic waves with cells is required to interpret the backscatter data. An overview of our efforts to model scattering from individual cells, cell ensembles, and in-vivo cancer will be presented. Theoretical results will be presented comparing scattering from individual cells with experimental data from a variety of cells in suspension, cell ensembles with pellets (compact aggregates of cells) and in-vivo tumors. It will be shown that for the tumors we have studied there is a very good correlation of scattering characteristics between cell pellets and in-vivo tumors, indicating that in the tumors studied cell structure was the factor that dominated the scattering response. The goal of this work is to use quantitative ultrasound methods for diagnosis and monitoring the response to therapy.
Authors:
Michael C Kolios; Gregory J Czarnota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  123     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2999     Citation Subset:  IM    
Affiliation:
Ryerson University, Department of Physics, 350 Victoria Street, Toronto, ON M5B2K3, Canada, mkolios@ryerson.ca.
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