Document Detail


Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation.
MedLine Citation:
PMID:  20803006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known mechanistically about why implanted glucose sensors lag behind blood glucose levels in both the time to peak sensor response and the magnitude of peak sensor response. A mathematical model of glucose transport from capillaries through surrounding tissue to the sensor surface was constructed to address how different aspects of the tissue affect glucose transport to an implanted sensor. Physiologically relevant values of capsule diffusion coefficient, capsule porosity, cellular glucose consumption, capsule thickness, and subcutaneous vessel density were used as inputs to create simulated sensor traces that mimic experimental instances of time lag and concentration attenuation relative to a given blood glucose profile. Using logarithmic sensitivity analysis, each parameter was analyzed to study the effect of these variables on both lag and attenuation. Results identify capsule thickness as the strongest determinant of sensor time lag, while subcutaneous vessel density and capsule porosity had the largest effects on attenuation of glucose that reaches the sensor surface. These findings provide mechanistic insight for the rational design of sensor modifications that may alleviate the deleterious consequences of tissue effects on implanted sensor performance.
Authors:
Matthew T Novak; Fan Yuan; William M Reichert
Related Documents :
24484306 - In vitro evaluation of a lateral expandable cage and its comparison with a static devic...
15219746 - Macropore resorbable devices in craniofacial surgery.
20629026 - Crosslinked urethane doped polyester biphasic scaffolds: potential for in vivo vascular...
23646326 - The use of miniscrew as orthodontic anchorage in correction of maxillary protrusion wit...
24734936 - Effectiveness and security of ct-guided percutaneous implantation of 125i seeds in panc...
18803086 - Evaluation of the patterns of potentially toxic exposures in mississippi following hurr...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-28
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  398     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2011-01-05     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1695-705     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Biosensing Techniques / instrumentation,  methods*
Diffusion
Glucose / chemistry,  pharmacokinetics*
Kinetics
Microvessels / metabolism
Models, Biological
Prostheses and Implants
Rats
Grant Support
ID/Acronym/Agency:
DK 54932/DK/NIDDK NIH HHS; R01 DK054932/DK/NIDDK NIH HHS; T32 GM 8555/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
IY9XDZ35W2/Glucose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Low-temperature co-fired ceramic microchannels with individually addressable screen-printed gold ele...
Next Document:  Optimization of parameters for coverage of low molecular weight proteins.