Document Detail


Modeling of porous scaffold deformation induced by medium perfusion.
MedLine Citation:
PMID:  24259467     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, we tested the possibility of calculating permeability of porous scaffolds utilized in soft tissue engineering using pore size and shape. We validated the results using experimental measured pressure drop and simulations with the inclusion of structural deformation. We prepared Polycaprolactone (PCL) and Chitosan-Gelatin (CG) scaffolds by salt leaching and freeze drying technique, respectively. Micrographs were assessed for pore characteristics and mechanical properties. Porosity for both scaffolds was nearly same but the permeability varied 10-fold. Elastic moduli were 600 and 9 kPa for PCL and CG scaffolds, respectively, while Poisson's ratio was 0.3 for PCL scaffolds and ∼1.0 for CG scaffolds. A flow-through bioreactor accommodating a 10 cm diameter and 0.2 cm thick scaffold was used to determine the pressure-drop at various flow rates. Additionally, computational fluid dynamic (CFD) simulations were performed by coupling fluid flow, described by Brinkman equation, with structural mechanics using a dynamic mesh. The experimentally obtained pressure drop matched the simulation results of PCL scaffolds. Simulations were extended to a broad range of permeabilities (10(-10) m(2) to 10(-14) m(2) ), elastic moduli (10-100,000 kPa) and Poisson's ratio (0.1-0.49). The results showed significant deviation in pressure drop due to scaffold deformation compared to rigid scaffold at permeabilities near healthy tissues. Also, considering the scaffold as a nonrigid structure altered the shear stress profile. In summary, scaffold permeability can be calculated using scaffold pore characteristics and deformation could be predicted using CFD simulation. These relationships could potentially be used in monitoring tissue regeneration noninvasively via pressure drop. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
Authors:
Jagdeep T Podichetty; Sundararajan V Madihally
Related Documents :
11014937 - A method to measure speaking time and speech sound pressure level.
7410227 - Intracochlear sound pressure measurements in guinea pigs.
23081857 - Biofeedback can reduce foot pressure to a safe level and without causing new at-risk zo...
7191807 - Effects of infrasound on the rota-rod treadmill performance of rats.
6661747 - A new apex-ejecting perfused rat heart preparation: relation between coronary flow and ...
15575127 - Pharmacotherapy and blood pressure control in elderly hypertensives in a primary care s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-21
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  -     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma, 74078.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor.
Next Document:  Tailoring Small Molecules for an Allosteric Site on Procaspase-6.