Document Detail


Modeling the pediatric paradox: birth weight by gestational age.
MedLine Citation:
PMID:  19350763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The "pediatric paradox" of African versus European American infant mortality is often observed with respect to birth weight, but rarely to gestational age, even though the two measures are biologically related. This paper models the pediatric paradox by birth weight and gestational age simultaneously, using Covariate Density Defined mixture of logistic regressions (CDDmlr) fitted to 1985-1988 New York State births. The model controls for unobserved heterogeneity and isolates the pediatric paradox in the "compromised" subpopulation. The paradox is not limited to low birth weights and/or short gestational ages, but surrounds the normal birth range. Nevertheless, the pediatric paradox is only observed in the marginal distribution of birth weight and not the marginal distribution of gestational age. These results are consistent with the hypothesis that higher fetal losses in the "compromised" subpopulation may be responsible for the pediatric paradox and that African versus European American infant mortality differentials are underestimated.
Authors:
Timothy B Gage; Fu Fang; Howard Stratton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Biodemography and social biology     Volume:  54     ISSN:  1948-5565     ISO Abbreviation:  Biodemography Soc Biol     Publication Date:  2008  
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-06-30     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101500303     Medline TA:  Biodemography Soc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-112     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Birth Weight*
Confidence Intervals
European Continental Ancestry Group
Female
Gestational Age*
Humans
Infant Mortality / trends*
Infant, Newborn
Logistic Models
Male
Models, Biological*
Multivariate Analysis
Pregnancy
United States
Grant Support
ID/Acronym/Agency:
HD37405/HD/NICHD NIH HHS; R01 HD037405-01A1/HD/NICHD NIH HHS; R01 HD037405-02/HD/NICHD NIH HHS; R01 HD037405-03/HD/NICHD NIH HHS; R01 HD037405-04A1/HD/NICHD NIH HHS; R01 HD037405-05/HD/NICHD NIH HHS; R01 HD037405-06/HD/NICHD NIH HHS
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