Document Detail

Modeling of pattern regulation in melanophores.
MedLine Citation:
PMID:  16959269     Owner:  NLM     Status:  MEDLINE    
Melanosomes, pigment granules in melanophores, play a principal role in physiological color adaptation of fish and frog. Melanophores regulate melanosome trafficking on cytoskeletal filaments to generate a range of spatiotemporal patterns. Here, we present the first comprehensive model of spatiotemporal evolution of melanosome patterns. The model encompasses both physical and biochemical aspects of melanosome dynamics. It consists of (i) a kinetic description of biochemical reactions involved in intracellular signaling, (ii) a system of macroscopic reaction-diffusion-convection equations for melanosome concentration, and (iii) a set of constitutive relationships for coupling transport with the biochemical network. The model relates molecular-level regulatory actions to cell-level melanosome distribution, allowing unification of existing experimental observations and qualitative hypotheses into an integrated, consistent framework. The model reproduces salient features of melanosome patterns, both during transient and steady state. It gives useful insights into how cells coordinate motor-assisted transport to maintain and adapt spatial organization of intracellular organelles. In particular, we calculate the optimal transition paths from aggregation to dispersion in fish melanophores. The calculations suggest that fish melanophores optimally control intracellular signaling to maximize the efficiency of motor-assisted transport during dispersion.
Anh-Tuan Dinh; Theo Theofanous; Samir Mitragotri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-26
Journal Detail:
Title:  Journal of theoretical biology     Volume:  244     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-53     Citation Subset:  IM    
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
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MeSH Terms
Adaptation, Physiological
Biological Transport / physiology
Cytoplasm / physiology
Melanophores / physiology*
Melanosomes / physiology
Models, Biological*
Molecular Motor Proteins / physiology
Pigments, Biological / metabolism
Signal Transduction / physiology
Reg. No./Substance:
0/Molecular Motor Proteins; 0/Pigments, Biological

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