Document Detail


Modeling pancreatic cancer in vivo: from xenograft and carcinogen-induced systems to genetically engineered mice.
MedLine Citation:
PMID:  20335777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the last 10 years, there has been a relative explosion of new rodent systems that recapitulate both genetic and cellular lesions that lead to the development of pancreatic cancer. These models now need to be considered when selecting an appropriate in vivo system to study disease etiology, cell signaling, and drug development. The majority of these evaluations have used transplantation of cancer cells and the use of carcinogens, which still maintain their value when investigating human cancer and epigenetic contributors. Xenograft models utilize cultured or primary pancreatic cancer cells that are placed under the skin or implanted within the pancreas of immunocompromised mice. Carcinogen-induced systems rely on administration of certain chemicals to generate cellular changes that rapidly lead to pancreatic cancer. Genetically modified mice are more advanced in their design in that relevant genetic mutations can be inserted into mouse genomic DNA in both a conditional and inducible manner. Generation of mice that develop spontaneous pancreatic cancer from a targeted genetic mutation is a valuable research tool, considering the broad spectrum of genes and cell targets that can be used, producing a variety of neoplastic lesions and cancer that can reflect many aspects of human pancreatic ductal adenocarcinoma.
Authors:
Yongzeng Ding; John D Cravero; Kevin Adrian; Paul Grippo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pancreas     Volume:  39     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-07-08     Revised Date:  2011-06-01    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-92     Citation Subset:  IM    
Affiliation:
Department of Surgery, Northwestern University, Chicago, IL 60611, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / pharmacology
Cell Transformation, Neoplastic / genetics,  pathology
Disease Models, Animal*
Homeodomain Proteins / genetics
Humans
Keratins / genetics
Mice*
Mice, Knockout
Mice, Transgenic
Pancreatic Elastase / genetics
Pancreatic Neoplasms* / chemically induced,  genetics,  pathology
Trans-Activators / genetics
Transcription Factors / genetics
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Homeodomain Proteins; 0/Trans-Activators; 0/Transcription Factors; 0/pancreatic and duodenal homeobox 1 protein; 0/transcription factor PTF1; 68238-35-7/Keratins; EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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