Document Detail

Modeling nucleic acids.
MedLine Citation:
PMID:  22538125     Owner:  NLM     Status:  MEDLINE    
Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and a diverse range of intricate three-dimensional nanostructures have been designed and synthesized. Different physical terms such as base-pairing and stacking interactions, tertiary contacts, electrostatic interactions and entropy all affect nucleic acid folding and structure. Here we review general computational approaches developed to model nucleic acid systems. We focus on four key areas of nucleic acid modeling: molecular representation, potential energy function, degrees of freedom and sampling algorithm. Appropriate choices in each of these key areas in nucleic acid modeling can effectively combine to aid interpretation of experimental data and facilitate prediction of nucleic acid structure.
Adelene Y L Sim; Peter Minary; Michael Levitt
Related Documents :
141645 - Some pharmacological observations on the analgesia induced by acupuncture in rabbits.
3034525 - Kainic acid: insights into excitatory mechanisms causing selective neuronal degeneration.
3509955 - Ibotenic acid analogues. synthesis and biological testing of two bicyclic 3-isoxazolol ...
8899305 - Effects of quisqualic acid on the corneal and intraretinal direct-current electroretino...
11576595 - Essential oil analysis of 10 piperaceae species from the brazilian atlantic forest.
6779625 - Preservation of urinary postprandial alkaline tide despite inhibition of gastric acid s...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-04-25
Journal Detail:
Title:  Current opinion in structural biology     Volume:  22     ISSN:  1879-033X     ISO Abbreviation:  Curr. Opin. Struct. Biol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-10-16     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  9107784     Medline TA:  Curr Opin Struct Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Computational Biology / methods
Models, Molecular*
Nucleic Acid Conformation
Nucleic Acids / chemistry*
Grant Support
Reg. No./Substance:
0/Nucleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of the Fukushima Dai-ichi nuclear accident on Spanish environmental radioactivity levels.
Next Document:  An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland.