Document Detail


Modeling of light absorption in tissue during infrared neural stimulation.
MedLine Citation:
PMID:  22894474     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A Monte Carlo model has been developed to simulate light transport and absorption in neural tissue during infrared neural stimulation (INS). A range of fiber core sizes and numerical apertures are compared illustrating the advantages of using simulations when designing a light delivery system. A range of wavelengths, commonly used for INS, are also compared for stimulation of nerves in the cochlea, in terms of both the energy absorbed and the change in temperature due to a laser pulse. Modeling suggests that a fiber with core diameter of 200 μm and NA=0.22 is optimal for optical stimulation in the geometry used and that temperature rises in the spiral ganglion neurons are as low as 0.1°C. The results show a need for more careful experimentation to allow different proposed mechanisms of INS to be distinguished.
Authors:
Alexander C Thompson; Scott A Wade; William G A Brown; Paul R Stoddart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  075002     Citation Subset:  IM    
Affiliation:
Swinburne University of Technology, Faculty of Engineering and Industrial Sciences, PO Box 218, Hawthorn, 3122, Australia.
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