Document Detail

Modeling of internal pH, ion concentration, and bioenergetic changes during myocardial ischemia.
MedLine Citation:
PMID:  9330737     Owner:  NLM     Status:  MEDLINE    
Arrhythmias are caused by the interdependent processes of change in energy metabolism and alterations in sarcolemmal ion gradients that occur during ischemia. Depletion of energy metabolites and increased proton concentrations in ischemic heart may underlie the observed phenomena of reduced contractile force and also of malignant ventricular arrhythmias that can lead to tachycardia and ventricular fibrillation. Recent advances in measuring changes in ion concentrations and metabolites during cardiac ischemia have provided a wealth of detail on the processes involved. Some of the experimental data have been used to construct a computer model that integrates cardiac energetics with electrophysiological changes. This is a novel approach to studying myocardial ischemia, and the resulting model would aid in the prediction of the effects of therapeutic interventions.
F Ch'en; K Clarke; R Vaughan-Jones; D Noble
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  430     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  281-90     Citation Subset:  IM    
Balliol College, University of Oxford, UK.
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MeSH Terms
Adenine Nucleotides / metabolism
Arrhythmias, Cardiac / etiology
Energy Metabolism*
Hydrogen-Ion Concentration
Models, Biological*
Myocardial Ischemia / metabolism*
Reg. No./Substance:
0/Adenine Nucleotides; 0/Ions

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