Document Detail


Modeling focal cerebral ischemia in vivo.
MedLine Citation:
PMID:  21913102     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischemic stroke is among the leading causes of mortality and long-term disability in the western world. Despite enormous research activities in the last decades, current therapeutic options for acute stroke patients are still very limited. Reliable and realistic in vivo animal models represent sine qua non for -successful translation from bench to bedside. To date, several animal models of focal and global cerebral ischemia have been developed to mimic the clinical situation in humans as accurately as possible. This chapter focuses on models of focal cerebral ischemia, in particular on the most commonly used model: the intraluminal filament model of middle cerebral artery occlusion. The main objective is to provide a detailed instruction manual for researchers interested in learning this technique.
Authors:
Katherine Jackman; Alexander Kunz; Costantino Iadecola
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  793     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-13     Completed Date:  2011-12-30     Revised Date:  2014-01-27    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-209     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheterization
Disease Models, Animal*
Femoral Artery / pathology,  physiopathology,  surgery
Hot Temperature
Infarction, Middle Cerebral Artery* / pathology,  physiopathology,  surgery
Male
Mice
Mice, Inbred C57BL
Nylons
Sutures
Grant Support
ID/Acronym/Agency:
R01 NS034179/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Nylons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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