| Modeling flow in a compromised pediatric airway breathing air and heliox. | |
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MedLine Citation:
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PMID: 19117302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: The aim of this study was to perform computer simulations of flow within an accurate model of a pediatric airway with subglottic stenosis. It is believed that the airflow characteristics in a stenotic airway are strongly related to the sensation of dyspnea. METHODS: Computed tomography images through the respiratory tract of an infant with subglottic stenosis were used to construct the three-dimensional geometry of the airway. By using computational fluid dynamics (CFD) modeling to capture airway flow patterns during inspiration and expiration, we obtained information pertaining to flow velocity, static airway wall pressure, pressure drop across the stenosis, and wall shear stress. These simulations were performed with both air and heliox (helium-oxygen mixture). RESULTS: Unlike air, heliox maintained laminar flow through the stenosis. The calculated pressure drop over stenosis was lower for the heliox flow in contrast to the airflow case. This led to an approximately 40% decrease in airway resistance when using heliox and presumably causes a decrease in the level of effort required for breathing. CONCLUSIONS: CFD simulations offer a quantitative method of evaluating airway flow dynamics in patients with airway abnormalities. CFD modeling illustrated the flow features and quantified flow parameters within a pediatric airway with subglottic stenosis. Simulations with air and heliox conditions mirrored the known clinical benefits of heliox compared with air. We anticipate that computer simulation models will ultimately allow a better understanding of changes in flow caused by specific medical and surgical interventions in patients with conditions associated with dyspnea. |
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Authors:
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Mihai Mihaescu; Ephraim Gutmark; Shanmugam Murugappan; Ravindhra Elluru; Aliza Cohen; J Paul Willging |
Publication Detail:
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Type: Journal Article; Retracted Publication |
Journal Detail:
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Title: The Laryngoscope Volume: 119 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-22 Completed Date: 2009-03-31 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 145-51 Citation Subset: IM |
Affiliation:
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Department of Aerospace Engineering and Engineering Mechanics, University of Cincinnati, Cincinnati, Ohio 45221-0070, USA. Mihai.Mihaescu@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pressure Airway Resistance / physiology Computer Simulation Helium / administration & dosage* Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Laryngostenosis / congenital, physiopathology*, therapy Models, Theoretical Oxygen / administration & dosage* Pediatrics / methods* Pulmonary Ventilation / physiology* Software Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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58933-55-4/heliox; 7440-59-7/Helium; 7782-44-7/Oxygen |
| Comments/Corrections | |
Retraction In:
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Johnson J. Laryngoscope. 2009 Jun;119(6):1256
[PMID:
19459165
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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