| Modeling the efficacy of triplet antimicrobial combinations: yeast suppression by lauric arginate, cinnamic acid, and sodium benzoate or potassium sorbate as a case study. | |
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MedLine Citation:
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PMID: 20202338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The growth of four spoilage yeasts, Saccharomyces cerevisiae, Zygosaccharomyces bailii, Brettanomyces bruxellensis, and Brettanomyces naardenensis, was inhibited with three-agent (triplet) combinations of lauric arginate, cinnamic acid, and sodium benzoate or potassium sorbate. The inhibition efficacy was determined by monitoring the optical density of yeast cultures grown in microtiter plates for 7 days. The relationship between the optical density and the sodium benzoate and potassium sorbate concentrations followed a single-term exponential decay model. The critical effective concentration was defined as the concentration at which the optical density was 0.05, which became an efficacy criterion for the mixtures. Critical concentrations of sodium benzoate or potassium sorbate as a function of the lauric arginate and cinnamic acid concentrations were then fitted with an empirical model that mapped three-agent combinations of equal efficacy. The contours of this function are presented in tabulated form and as two- and three-dimensional plots. Triplet combinations were highly effective against all four spoilage yeasts at three practical pH levels, especially at pH 3.0. The triplet combinations were particularly effective for inhibiting growth of Z. bailii, and combinations containing potassium sorbate had synergistic activities. The equal efficacy concentration model also allowed tabulation of the cost of the various combinations of agents and identification of those most economically feasible. |
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Authors:
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Yumei Dai; Mark D Normand; Jochen Weiss; Micha Peleg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food protection Volume: 73 ISSN: 0362-028X ISO Abbreviation: J. Food Prot. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703944 Medline TA: J Food Prot Country: United States |
Other Details:
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Languages: eng Pagination: 515-23 Citation Subset: IM |
Affiliation:
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Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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pharmacology* Brettanomyces / drug effects, growth & development Cinnamates / pharmacology Colony Count, Microbial Consumer Product Safety Drug Combinations Drug Synergism Food Contamination / analysis, prevention & control* Food Microbiology Food Preservatives / pharmacology* Humans Hydrogen-Ion Concentration Laurates / pharmacology Microbial Sensitivity Tests Saccharomyces cerevisiae / drug effects, growth & development Sodium Benzoate / pharmacology Sorbic Acid / pharmacology Yeasts / drug effects*, growth & development Zygosaccharomyces / drug effects, growth & development |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Cinnamates; 0/Drug Combinations; 0/Food Preservatives; 0/Laurates; 110-44-1/Sorbic Acid; 532-32-1/Sodium Benzoate; 621-82-9/cinnamic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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