Document Detail

Modeling effects of age and sex on cardiovascular variability responses to aerobic ergometer exercise.
MedLine Citation:
PMID:  17985166     Owner:  NLM     Status:  MEDLINE    
After collecting data on the cardiovascular responses to ramp-type exercise tests on a cycle ergometer from 194 healthy male and female subjects aged from 20 to 69 years, we constructed a mathematical model that simulates typical patterns of the cardiovascular variability responses to ramp-type exercise loads below the anaerobic threshold. This was done by reflecting the following physiological mechanisms: (1) suppression of parasympathetic nerve activity, (2) reduction of total peripheral resistance, (3) resetting of the operating point in the baroreflex curve, (4) increase in stroke volume, and (5) increase in the coupling of stroke volume to pulse pressure. We estimated the values of model parameter that best fit the measured experimental data. The estimated steepness of the slope with which parasympathetic nerve activity decreased was lower in subjects with a higher anaerobic threshold, tended to increase with age, and in every age decade was higher for females than for males.
Kohzoh Yoshino; Kimihiro Adachi; Keiko Ihochi; Katsunori Matsuoka
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Publication Detail:
Type:  Journal Article     Date:  2007-11-06
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  45     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1085-93     Citation Subset:  IM    
Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan.
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MeSH Terms
Aging / physiology*
Blood Pressure / physiology
Ergometry / methods
Exercise / physiology*
Heart Rate / physiology
Models, Cardiovascular*
Sex Characteristics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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