Document Detail


Modeling of drug release from biodegradable triple-layered microparticles.
MedLine Citation:
PMID:  22733705     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Numerous models that predict drug release from nonerodible reservoir-membrane sphere systems have been presented. Most of these models cater only to a phase of drug release from a constant reservoir. All these models, however, are not applicable to drug release from biodegradable triple-layered microparticle system, in which the drug-loaded core (reservoir) is surrounded by nondrug holding outer layers (membrane). In this article, a mathematical model was developed for ibuprofen release from degradable triple-layered microparticles made of poly(D,L-lactide-co-glycolide, 50:50) (PLGA), poly(L-lactide) (PLLA), and poly(ethylene-co-vinyl acetate, 40 wt % vinyl acetate) (EVA), where ibuprofen was localized within the nonconstant reservoir (EVA core). The model postulated that the drug release through the bulk-degrading PLLA and PLGA layers consisted of two mechanisms: simple diffusional release followed by a degradation-controlled release through a rate-limiting membrane. The proposed model showed very good match with the experimental data of release from microparticles of various layer thicknesses and particle sizes. The underlying drug release mechanisms are dictated by three parameters determined by the model, including constant characteristic of diffusion, end time point of simple diffusion-controlled release and partition coefficient of drug. The presented model is effective for understanding the drug release mechanisms and for the design of this type of dosage form. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Authors:
Wei Li Lee; Wen-Xiong Shi; Zheng Yang Low; Shuzhou Li; Say Chye Joachim Loo
Related Documents :
22643315 - Tamoxifen-loaded novel liposomal formulations: evaluation of anticancer activity on dmb...
22768185 - High-throughput screening and sensitized bacteria identify an m. tuberculosis dihydrofo...
22773965 - Degrees of chloroquine resistance in plasmodium - is the redox system involved?
22879935 - Markov models of use-dependence and reverse use-dependence during the mouse cardiac act...
7201815 - The use of thermography in the evaluation of the anti-inflammatory activity of feprazon...
8202865 - The use of paxirasol in clinical practice.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-26
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  -     ISSN:  1552-4965     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The identification and chemical characterization of a new arylcyclohexylamine, methoxetamine, using ...
Next Document:  Platelet-rich plasma loaded in situ-formed hydrogel enhances hyaline cartilage regeneration by CB1 u...