Document Detail

Modeling developmental patterns of spontaneous activity.
MedLine Citation:
PMID:  21684148     Owner:  NLM     Status:  MEDLINE    
Spontaneous activity is found in many regions of the developing nervous system; such activity is thought to be instructive for guiding developmental processes. In particular, the developing retina generates correlated patterns of activity known as retinal waves. We review the main theoretical models that have been developed to study the mechanisms for generation and propagation of retinal waves. Much of the progress in this field has been due to the close interaction between experimentalists and theorists in analyzing and modeling spontaneous activity. We conclude by describing spontaneous activity models in other systems and suggestions for future modeling work.
Julijana Gjorgjieva; Stephen J Eglen
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-06-16
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  21     ISSN:  1873-6882     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-23     Completed Date:  2012-03-20     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Cambridge Computational Biology Institute, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK.
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MeSH Terms
Models, Neurological*
Neurons / classification,  physiology*
Retina / cytology*,  growth & development*
Vision, Ocular / physiology*
Visual Pathways / physiology
Grant Support
083205//Wellcome Trust

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