Document Detail

Modeling the conductance and DNA blockade of solid-state nanopores.
MedLine Citation:
PMID:  21730759     Owner:  NLM     Status:  MEDLINE    
We present measurements and theoretical modeling of the ionic conductance G of solid-state nanopores with 5-100 nm diameters, with and without DNA inserted into the pore. First, we show that it is essential to include access resistance to describe the conductance, in particular for larger pore diameters. We then present an exact solution for G of an hourglass-shaped pore, which agrees very well with our measurements without any adjustable parameters, and which is an improvement over the cylindrical approximation. Subsequently we discuss the conductance blockade ΔG due to the insertion of a DNA molecule into the pore, which we study experimentally as a function of pore diameter. We find that ΔG decreases with pore diameter, contrary to the predictions of earlier models that forecasted a constant ΔG. We compare three models for ΔG, all of which provide good agreement with our experimental data.
Stefan W Kowalczyk; Alexander Y Grosberg; Yitzhak Rabin; Cees Dekker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-06
Journal Detail:
Title:  Nanotechnology     Volume:  22     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-11-01     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  England    
Other Details:
Languages:  eng     Pagination:  315101     Citation Subset:  IM    
Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands.
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MeSH Terms
DNA / chemistry*
Electric Conductivity
Ions / chemistry
Models, Chemical
Nanopores* / ultrastructure
Reg. No./Substance:
0/Ions; 9007-49-2/DNA
Comment In:
Nanotechnology. 2012 Mar 2;23(8):088001; author reply 088002   [PMID:  22293129 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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