| Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior. | |
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MedLine Citation:
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PMID: 22236531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes. |
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Authors:
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Jongmin Shim; Anna Grosberg; Janna C Nawroth; Kevin Kit Parker; Katia Bertoldi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-01-10 |
Journal Detail:
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Title: Journal of biomechanics Volume: 45 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-09-11 Revised Date: 2013-03-21 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 832-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Engineering and Applied Science, Harvard University, Cambridge, MA, United States. jshim@seas.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Elastic Modulus / physiology Elasticity / physiology Models, Cardiovascular* Myocytes, Cardiac / physiology* Rats Tissue Engineering / methods |
| Grant Support | |
ID/Acronym/Agency:
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1 R01HL079126/HL/NHLBI NIH HHS; R01 HL079126-01A1/HL/NHLBI NIH HHS; U01 HL100408/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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