Document Detail


Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior.
MedLine Citation:
PMID:  22236531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes.
Authors:
Jongmin Shim; Anna Grosberg; Janna C Nawroth; Kevin Kit Parker; Katia Bertoldi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-01-10
Journal Detail:
Title:  Journal of biomechanics     Volume:  45     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-09-11     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  832-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Elastic Modulus / physiology
Elasticity / physiology
Models, Cardiovascular*
Myocytes, Cardiac / physiology*
Rats
Tissue Engineering / methods
Grant Support
ID/Acronym/Agency:
1 R01HL079126/HL/NHLBI NIH HHS; R01 HL079126/HL/NHLBI NIH HHS; R01 HL079126-01A1/HL/NHLBI NIH HHS; U01 HL100408/HL/NHLBI NIH HHS

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