| Modeling the blood lactate kinetics at maximal short-term exercise conditions in children, adolescents, and adults. | |
| | |
MedLine Citation:
|
PMID: 16020438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Whether age-related differences in blood lactate concentrations (BLC) reflect specific BLC kinetics was analyzed in 15 prepubescent boys (age 12.0 +/- 0.6 yr, height 1.54 +/- 0.06 m, body mass 40.0 +/- 5.2 kg), 12 adolescents (16.3 +/- 0.7 yr, 1.83 +/- 0.07 m, 68.2 +/- 7.5 kg), and 12 adults (27.2 +/- 4.5 yr, 1.83 +/- 0.06 m, 81.6 +/- 6.9 kg) by use of a biexponential four-parameter kinetics model under Wingate Anaerobic Test conditions. The model predicts the lactate generated in the extravasal compartment (A), invasion (k(1)), and evasion (k(2)) of lactate into and out of the blood compartment, the BLC maximum (BLC(max)), and corresponding time (TBLC(max)). BLC(max) and TBLC(max) were lower (P < 0.05) in boys (BLC(max) 10.2 +/- 1.3 mmol/l, TBLC(max) 4.1 +/- 0.4 min) than in adolescents (12.7 +/- 1.0 mmol/l, 5.5 +/- 0.7 min) and adults (13.7 +/- 1.4 mmol/l, 5.7 +/- 1.1 min). No differences were found in A related to the muscle mass (A(MM)) and k(1) between boys (A(MM): 22.8 +/- 2.7 mmol/l, k(1): 0.865 +/- 0.115 min(-1)), adolescents (22.7 +/- 1.3 mmol/l, 0.692 +/- 0.221 min(-1)), and adults (24.7 +/- 2.8 mmol/l, 0.687 +/- 0.287 min(-1)). The k(2) was higher (P < 0.01) in boys (2.87 10(-2) +/- 0.75 10(-2) min(-1)) than in adolescents (2.03 x 10(-2) +/- 0.89 x 10(-2) min(-1)) and adults (1.99 x 10(-2) +/- 0.93 x 10(-2) min(-1)). Age-related differences in the BLC kinetics are unlikely to reflect differences in muscular lactate or lactate invasion but partly faster elimination out of the blood compartment. |
| | |
Authors:
|
Ralph Beneke; Matthias Hütler; Marcus Jung; Renate M Leithäuser |
Related Documents
:
|
10776898 - Intra- and extra-cellular lactate shuttles. 9007458 - Lactate/h+ uptake by red blood cells during exercise alters their physical properties. 19122058 - Evaluations of labrador retrievers with exercise-induced collapse, including response t... 11548918 - Physiological profiles of australian surf boat rowers. 15929958 - Randomised trial of ambulatory oxygen in oxygen-dependent copd. 2790228 - Exercise stress alters the percentage of splenic lymphocyte subsets in response to mito... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 99 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-07-15 Completed Date: 2005-09-30 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 499-504 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom. rbeneke@essex.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aging / physiology* Child Computer Simulation Humans Kinetics Lactic Acid / blood* Male Metabolic Clearance Rate Models, Biological* Muscle, Skeletal / physiology* Physical Endurance / physiology* Physical Exertion / physiology* |
| Chemical | |
Reg. No./Substance:
|
50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The physiological challenges of the 1952 Copenhagen poliomyelitis epidemic and a renaissance in clin...
Next Document: Fat as an endocrine organ: influence of exercise.