Document Detail

Modeling amino acid metabolism in mammalian cells-toward the development of a model library.
MedLine Citation:
PMID:  17949105     Owner:  NLM     Status:  MEDLINE    
Amino acids are necessary to mammalian cell cultures both for protein synthesis and as an energy source. In this study, we present an unstructured mathematical model describing (i) cell growth and death kinetics and (ii) metabolism of glucose and 19 amino acids for HEK-293 and CHO IFN-gamma cell cultures. The proposed mathematical framework is in good agreement with experimental data for both cell lines. It accommodates the inclusion of expressions for other cellular activities, such as the production of recombinant viral vectors or proteins, and can be used as the basis for the development of a model library for mammalian cell cultures.
Cleo Kontoravdi; Danny Wong; Carolyn Lam; Yih Yean Lee; Miranda G S Yap; Efstratios N Pistikopoulos; Athanasios Mantalaris
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Publication Detail:
Type:  Journal Article     Date:  2007-10-20
Journal Detail:
Title:  Biotechnology progress     Volume:  23     ISSN:  8756-7938     ISO Abbreviation:  Biotechnol. Prog.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-03-04     Revised Date:  2008-03-13    
Medline Journal Info:
Nlm Unique ID:  8506292     Medline TA:  Biotechnol Prog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1261-9     Citation Subset:  IM    
Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
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MeSH Terms
Amino Acids / metabolism*
CHO Cells
Databases, Factual*
Glucose / metabolism
Models, Theoretical
Reg. No./Substance:
0/Amino Acids; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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