| Modeling the acute- and late-phase responses to peripheral airway cooling and desiccation. | |
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MedLine Citation:
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PMID: 12070205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute bronchoconstriction after isocapnic hyperpnea can be produced in most asthmatic individuals. However, the existence of a late-phase response is less certain. We used a canine model of isocapnic hyperpnea to test the hypothesis that this discrepancy is due to differences in the challenge threshold for the responses. Acute-phase and late-phase bronchoconstriction was measured in nine dogs after peripheral airway exposure to unconditioned air. Additionally, bronchoalveolar lavage fluid (BALF) was obtained during the late-phase response. The acute-phase response was a polynomial function with a decreasing slope at higher challenges, whereas the late-phase response suggested that a minimum threshold of challenge severity was needed to produce late-phase bronchoconstriction. BALF leukocyte and eicosanoid concentrations had linear relationships with challenge severity. Our data support the hypothesis that acute- and late-phase posthyperpnea responses have different dose-response relationships, a fact that may explain the frequent lack of a late-phase response. However, our data suggest that mild inflammation can be induced with relatively lower challenge severity. |
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Authors:
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Michael S Davis; Chris M Royer; Mark Payton; Brian Buttress |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 93 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-18 Completed Date: 2002-12-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Department of Physiological Sciences, Oklahoma State University, Stillwater 74078, USA. msdavis@okstate.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Reaction
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physiopathology* Airway Resistance / physiology Animals Bronchi / blood supply, physiology* Bronchoalveolar Lavage Fluid / chemistry, cytology Bronchoconstriction / physiology* Bronchoscopy Cold Temperature / adverse effects* Desiccation* Dogs Eicosanoids / metabolism Humidity Leukocytes / physiology Models, Biological Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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