| Modeling T- and B-cell growth and differentiation. | |
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MedLine Citation:
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PMID: 17367338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The control of T- and B-cell proliferation following antigen stimulation lies at the heart of the adaptive immune response. The outcome of a response depends on the number of cells that are activated to go into cycle, the rates at which the cells divide and die, and the number of division cycles the cells undergo. Each of these processes may be under independent control, and the precise outcome of T- or B-cell responses to antigen will depend on how the signals controlling the different events are integrated. In this article, the way different mathematical models in combination with data from carboxyfluorescein diacetate succinamidyl ester (CFSE) experiments can be used to investigate the mechanisms controlling T- and B-cell proliferation is reviewed. |
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Authors:
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Robin Callard; Phil Hodgkin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunological reviews Volume: 216 ISSN: 0105-2896 ISO Abbreviation: Immunol. Rev. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 119-29 Citation Subset: IM |
Affiliation:
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Immunobiology Unit, Institute of Child Health, University College London, London, UK. rcallard@ich.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis B-Lymphocytes / cytology, drug effects, immunology* Cell Differentiation Fluoresceins / pharmacology Humans Lymphocyte Activation* Models, Immunological* Succinimides / pharmacology T-Lymphocytes / cytology, drug effects, immunology* |
| Chemical | |
Reg. No./Substance:
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0/5-(6)-carboxyfluorescein diacetate succinimidyl ester; 0/Fluoresceins; 0/Succinimides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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