| Modeling O₂ transport as an integrated system limiting (.)V(O₂MAX). | |
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MedLine Citation:
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PMID: 20483502 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maximal endurance exercise capacity is determined by a variety of factors, including maximal ability to transport O₂ to the muscle mitochondria and to use this O₂ for ATP generation ((.)V(O₂MAX)). This analysis combines the individually well-known O₂ mass conservation equations for the four critical steps in the O₂ transport pathway (ventilation, alveolar/capillary diffusion, circulation and muscle diffusion) into an analytical, closed form, model showing how (.)V(O₂MAX) depends on all four steps. It further shows how changes in any one step affect the function of the others. This analytical approach however requires approximating the O₂Hb dissociation curve as linear. Removing this condition to allow for the real O₂Hb curve requires numerical analysis best explained graphically. Incorporating maximal mitochondrial metabolic capacity to use O₂ allows prediction of when (.)V(O₂MAX) is limited by transport or by metabolic capacity. This simple approach recapitulates in vivo behavior and clarifies the determinants of maximal exercise. |
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Authors:
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Peter D Wagner |
Publication Detail:
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Type: Journal Article Date: 2010-05-18 |
Journal Detail:
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Title: Computer methods and programs in biomedicine Volume: 101 ISSN: 1872-7565 ISO Abbreviation: Comput Methods Programs Biomed Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-06-02 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8506513 Medline TA: Comput Methods Programs Biomed Country: Ireland |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093-0623A, USA. pdwagner@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Oxygen / metabolism* Physical Endurance Respiratory Function Tests |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL091830-01A18100/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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