| Modeling O(2)-Dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O(2) Transport around Arterioles. | |
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MedLine Citation:
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PMID: 21445797 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent evidence in the literature suggests that tissues play a greater role than blood in reducing nitrite to NO under ischemic or hypoxic conditions. Our previous mathematical model for coupled NO and O(2) transport around an arteriole, modified to include superoxide generation from dysfunctional endothelium, was developed further to include nitrite reductase activity in blood and tissue. Steady-state radial and axial NO and pO(2) profiles in the arteriole and surrounding tissue were simulated for different blood flow rates and arterial blood pO(2) values. The resulting computer simulations demonstrate that nitrite reductase activity in blood is not a very effective mechanism for conserving NO due to the strong scavenging of NO by hemoglobin. In contrast, nitrite reductase activity in tissue is much more effective in increasing NO bioavailability in the vascular wall and contributes progressively more NO as tissue hypoxia becomes more severe. |
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Authors:
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Donald G Buerk; Kenneth A Barbee; Dov Jaron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 915 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 271-6 Citation Subset: IM |
Affiliation:
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School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA, dgb28@drexel.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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