Document Detail


Modeling Nosocomial Transmission of Rotavirus in Pediatric Wards.
MedLine Citation:
PMID:  20811781     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nosocomial transmission of viral and bacterial infections is a major problem worldwide, affecting millions of patients (and causing hundreds of thousands of deaths) per year. Rotavirus infections affect most children worldwide at least once before age five. We present here deterministic and stochastic models for the transmission of rotavirus in a pediatric hospital ward and draw on published data to compare the efficacy of several possible control measures in reducing the number of infections during a 90-day outbreak, including cohorting, changes in healthcare worker-patient ratio, improving compliance with preventive hygiene measures, and vaccination. Although recently approved vaccines have potential to curtail most nosocomial rotavirus transmission in the future, even short-term improvement in preventive hygiene compliance following contact with symptomatic patients may significantly limit transmission as well, and remains an important control measure, especially where resources are limited.
Authors:
Christopher M Kribs-Zaleta; Jean-François Jusot; Philippe Vanhems; Sandrine Charles
Publication Detail:
Type:  Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Bulletin of mathematical biology     Volume:  73     ISSN:  1522-9602     ISO Abbreviation:  Bull. Math. Biol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401404     Medline TA:  Bull Math Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1413-42     Citation Subset:  IM    
Affiliation:
CNRS, UMR5558, Laboratoire de Biométrie et Biologie Évolutive, Université Lyon 1, Université de Lyon, 69622, Villeurbanne, France, kribs@uta.edu.
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