Document Detail

Modeling motivational deficits in mouse models of schizophrenia: behavior analysis as a guide for neuroscience.
MedLine Citation:
PMID:  21338658     Owner:  NLM     Status:  MEDLINE    
In recent years it has become possible to develop animal models of psychiatric disease in genetically modified mice. While great strides have been made in the development of genetic and neurobiological tools with which to model psychiatric disease, elucidation of neural and molecular mechanisms thought to underlie behavioral phenotypes has been hindered by an inadequate analysis of behavior. This is unfortunate given the fact that the experimental analysis of behavior has created powerful methods for isolating and describing the functional properties of behavioral mechanisms that are capable of providing deep understanding of behavioral phenotypes. A better understanding of the biological basis of normal behavior and its disturbance in psychiatric disease will require the application of these rigorous behavior analytic tools to animal models. In this review we provide an example of a merging of genetic and behavioral methods and illustrate its utility in the analysis of a mouse model of the motivational deficits in schizophrenia. The synergy between basic behavior analysis, neuroscience, and animal models of psychiatric disease has great potential for achieving a deeper understanding of behavior and its neurobiological mechanisms as well as for leading to improvements in diagnosis and treatment in clinical settings.
Ryan D Ward; Eleanor H Simpson; Eric R Kandel; Peter D Balsam
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-02-18
Journal Detail:
Title:  Behavioural processes     Volume:  87     ISSN:  1872-8308     ISO Abbreviation:  Behav. Processes     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-17     Revised Date:  2014-05-19    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Behavior, Animal / physiology*
Disease Models, Animal
Schizophrenia / physiopathology*
Grant Support
F32 MH090750-01A1/MH/NIMH NIH HHS; L30 RR030262-01/RR/NCRR NIH HHS; P50 MH086404/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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