Document Detail


Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model.
MedLine Citation:
PMID:  22588575     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Due to the growing shortage of donor livers, more patients are waiting for transplantation. Living donor liver transplantation may help expanding the donor pool, but is often confronted with the small-for-size syndrome. Since the hemodynamic effects of partial hepatectomy are not fully understood, we developed an electrical rat liver model to compare normal with resected liver hemodynamics. Detailed geometrical data and 3D reconstructions of the liver vasculature of two rats were gathered by combining vascular corrosion casting, micro-CT scanning and image processing. Data extrapolations allowed obtaining a total liver pressure- and flow-driven electrical analogue. Subsequently, virtual resections led to 70%, 80% or 90% partial hepatectomy models. Results demonstrated hyperperfusion effects such as portal hypertension and elevated lobe-specific portal venous flows (11 mmHg, 12 mmHg, 24 mmHg and 1.0-3.0 ml/min, 1.8-3.5 ml/min, 7.4 ml/min for 70%, 80%, 90% hepatectomy, respectively). Comparison of two 90% resection techniques demonstrated different total arterial flows (0.28 ml/min versus 0.61 ml/min), portal (24 mmHg versus 21 mmHg) and sinusoidal pressures (14 mmHg versus 9.5- 12 mmHg), probably leading to better survival for lower portal and sinusoidal pressures. Towards the future, the models may be extrapolated to human livers and help to optimize hepatectomy planning.
Authors:
C Debbaut; D De Wilde; C Casteleyn; P Cornillie; D Van Loo; L Van Hoorebeke; D Monbaliu; Y Fan; P Segers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-11
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  -     ISSN:  1558-2531     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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