Document Detail

Modeling the 3D functional architecture of the nucleus in animal and plant kingdoms.
MedLine Citation:
PMID:  19909917     Owner:  NLM     Status:  MEDLINE    
Compartmentalization is one of the fundamental principles which underly nuclear function. Numerous studies describe complex and sometimes conflicting relationships between nuclear gene positioning and transcription regulation. Therefore the question is whether topological landmarks and/or organization principles exist to describe the nuclear architecture and, if existing, whether these principles are identical in the animal and plant kingdoms. In the frame of an agroBI-INRA program on nuclear architecture, we set up a multidisciplinary approach combining biological studies, spatial statistics and 3D modeling to investigate spatial organization of a nuclear compartment in both plant and animal cells in their physiological contexts. In this article, we review the questions addressed in this program and the methodology of our work.
Val?rie Gaudin; Philippe Andrey; Eve Devinoy; Cl?mence Kress; Ki?n Kieu; Nathalie Beaujean; Yves Maurin; Pascale Debey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-15
Journal Detail:
Title:  Comptes rendus biologies     Volume:  332     ISSN:  1768-3238     ISO Abbreviation:  C. R. Biol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  937-46     Citation Subset:  IM    
Laboratoire de biologie cellulaire, UR501, IJPB, route de Saint-Cyr, INRA, 78026 Versailles, France.
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MeSH Terms
Arabidopsis / cytology
Blastocyst / cytology
Cell Compartmentation
Cell Differentiation
Cell Nucleus / physiology,  ultrastructure*
Eukaryotic Cells / physiology,  ultrastructure*
Gene Expression Regulation
Gene Expression Regulation, Plant
Image Processing, Computer-Assisted
Mammary Glands, Animal / cytology
Models, Biological*
Plants / cytology*,  genetics
Protoplasts / ultrastructure
Systems Biology / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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