Document Detail


Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts.
MedLine Citation:
PMID:  25260175     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Several previous studies, mostly cross-sectional, have found associations between perfluorooctanoic acid (PFOA) and high cholesterol levels, but studies of hypertension and heart disease have had inconsistent findings.
OBJECTIVES: This study examined the association between modeled PFOA exposure and incident hypertension, hypercholesterolemia, and coronary artery disease among workers at a Mid-Ohio Valley chemical plant that used PFOA, and residents of the surrounding community.
METHODS: Community- and worker-cohort participants completed surveys during 2008-2011 covering demographics, health-related behaviors, and medical history. Cox proportional hazard models, stratified by birth year, modeled the hazard of each outcome (starting at age 20) as a function of retrospective serum PFOA concentration estimates (generated through fate, transport and exposure modeling), controlling for gender, race, education, smoking, alcohol use, body mass index, and diabetes.
RESULTS: Among 32,254 participants (28,541 community; 3,713 worker), 12,325 reported hypertension with medication, 9,909 reported hypercholesterolemia with medication, and 3,147 reported coronary artery disease (2,550 validated). Hypercholesterolemia incidence increased with increasing cumulative PFOA exposure (sum of yearly serum concentration estimates), most notably among males aged 40-60 years. Compared with the lowest exposure quintile (<142 ng/ml-years), hazard ratios for subsequent quintiles (ng/ml-years: 142-<234; 234-<630; 630-<3579; ≥3579) were 1.24, 1.17, 1.19 and 1.19 overall and 1.38, 1.32, 1.31, and 1.44 among men aged 40-60 years. There was no apparent association between PFOA exposure and hypertension or coronary artery disease incidence.
CONCLUSIONS: Higher PFOA exposure was associated with incident hypercholesterolemia with medication, but not with hypertension or coronary artery disease.
Authors:
Andrea Winquist; Kyle Steenland
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Environmental health perspectives     Volume:  -     ISSN:  1552-9924     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-26     Completed Date:  -     Revised Date:  2014-9-27    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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